| First round |
| 29 September 1877 | 1st Lanark Rifle Volunteers | 1 | - | 0 | Blythswood | |
| 29 September 1877 | 3rd Edinburgh Rifle Volunteers | 0 | - | 0 | Swifts | |
| 29 September 1877 | 10th Dumbarton Rifle Volunteers | 1 | - | 0 | Star of Leven | |
| 29 September 1877 | 23rd Renfrew Rifle Volunteers | 1 | - | 0 | Levern | |
| 29 September 1877 | Alexandra Athletic | 2 | - | 0 | Lancefield | |
| 29 September 1877 | Alexandria | 0 | - | 2 | Milngavie | |
| 29 September 1877 | Arthurlie | 3 | - | 0 | Busby | |
| 29 September 1877 | Ayr Academicals | 4 | - | 1 | Vale of Calder | |
| Walkover | Ayr Thistle | | | | St Andrew's | Scratched |
| 6 October 1877 | Barrhead | 7 | - | 0 | Morton | |
| 29 September 1877 | Beith | 1 | - | 0 | Catrine | |
| Walkover | Blackfriars | | | | Hyde Park Locomotive Works | Scratched |
| 29 September 1877 | Clifton & Strathfillan | 2 | - | 1 | Shaugraun | |
| 29 September 1877 | Clyde | 0 | - | 1 | Third Lanark Rifle Volunteers | |
| 29 September 1877 | Clydesdale | 3 | - | 0 | Dennistoun | |
| Walkover | Derby | | | | Dumbreck | Scratched |
| 29 September 1877 | Dumbarton | 4 | - | 0 | Waverley | |
| 29 September 1877 | Glenkilloch | 2 | - | 0 | Wellington Park | |
| 29 September 1877 | Govan | 6 | - | 0 | Albatross | |
| 6 October 1877 | Hamilton | 1 | - | 0 | Avondale | |
| 29 September 1877 | Hanover | 1 | - | 0 | Edinburgh Thistle | |
| 29 September 1877 | Havelock | 6 | - | 0 | Craig Park | |
| 29 September 1877 | Heart of Midlothian | 0 | - | 0 | Hibernian | |
| 22 September 1877 | Jordanhill | 1 | - | 0 | Queen's Park Juniors | |
| 29 September 1877 | Kelvinbank | 3 | - | 2 | Petershill | |
| 29 September 1877 | Kilbirnie | 6 | - | 0 | Dean | |
| 29 September 1877 | Kilmarnock | 5 | - | 1 | Hurtford | |
| 29 September 1877 | Kilmarnock Cricket & Football Club | 4 | - | 0 | Maybole Thistle | |
| 29 September 1877 | Kilmarnock Portland | 1 | - | 0 | Cumnock | |
| 6 October 1877 | Lennox | 2 | - | 0 | Helensburgh | |
| 29 September 1877 | Lenzie | 2 | - | 0 | Ailsa | |
| 29 September 1877 | Mauchline | 6 | - | 0 | Girvan | |
| 29 September 1877 | Maybole Carrick | 1 | - | 1 | Tarbolton Burntonians | |
| not known | Mount Vernon | 1 | - | 2 | Glengowan | |
| 22 September 1877 | Newmains | 1 | - | 3 | Uddingston | |
| 29 September 1877 | Northern | 3 | - | 0 | Pollockshields Athletic | |
| 22 September 1877 | Oxford | 0 | - | 1 | Sandyford | |
| Walkover | Parkgrove | | | | Winton | Scatched |
| 22 September 1877 | Partick | 2 | - | 0 | Union | |
| 6 October 1877 | Queen of the South Wanderers | 6 | - | 0 | Stranraer | |
| 29 September 1877 | Queen's Park | 9 | - | 0 | Whiteinch | |
| 29 September 1877 | Ramblers | 0 | - | 1 | Stonefield | |
| 6 October 1877 | Rangers | 13 | - | 0 | Possilpark | |
| 29 September 1877 | Renfrew | 0 | - | 0 | Pollockshaws Athletic | |
| Walkover | Renton | | | | Vale of Leven Rovers | Scratched |
| 6 October 1877 | Renton Thistle | 2 | - | 0 | Alcutha | |
| 29 September 1877 | Rovers | 0 | - | 0 | John Elder | |
| 6 October 1877 | Shaftesbury | 2 | - | 3 | Rosslyn | |
| 6 October 1877 | Shotts | 2 | - | 3 | Drumpelier | |
| 29 September 1877 | South Western | 8 | - | 0 | Dundee Old Boys | |
| Walkover | St Clement's | | | | Dunfermline | Scratched |
| 29 September 1877 | Stonelaw | 1 | - | 1 | Airdrie | |
| 29 September 1877 | Strathclyde | 5 | - | 1 | West End | |
| 29 September 1877 | Telegraphists | 1 | - | 0 | 4th Renfrew Rifle Volunteers | |
| 29 September 1877 | Thornliebank | 1 | - | 0 | Port Glasgow | |
| Walkover | Vale of Leven | | | | Kilmarnock Thistle | Scatched |
| Bye | Caledonian | | | | | |
| Bye | Dunmore | | | | | |
| Bye | Grasshoppers | | | | | |
| Bye | 17th Renfrew Rifle Volunteers | | | | | |
| Replays |
| 13 October 1877 | Airdrie | 0 | - | 2 | Stonelaw | |
| 6 October 1877 | Hibernian | 2 | - | 1 | Heart of Midlothian | |
| 6 October 1877 | Pollokshaws Athletic | 0 | - | 2 | Renfrew | |
| 6 October 1877 | Rovers | 2 | - | 2 | John Elder | Both teams advanced to next rund |
| 6 October 1877 | Swifts | 2 | - | 1 | 3rd Edinburgh Rifle Volunteers | |
| 6 October 1877 | Tarbolton Burntonians | 0 | - | 3 | Maybole Carrick | |
| Second round |
| 20 October 1877 | 1st Lanark Rifle Volunteers | 4 | - | 0 | Telegraphists | |
| 27 October 1877 | 3rd Lanark Rifle Volunteers | 11 | - | 0 | Derby | |
| 20 October 1877 | Arthurlie | 1 | - | 0 | 17th Renfrew Rifle Volunteers | |
| 20 October 1877 | Ayr Academicals | 1 | - | 0 | Kilmarnock | |
| 20 October 1877 | Ayr Thistle | 0 | - | 0 | Kilbirnie | |
| 27 October 1877 | Beith | 1 | - | 0 | Kilmarnock Portland | |
| 20 October 1877 | Blackfriars | 2 | - | 2 | Rovers | |
| 20 October 1877 | Caledonian | 1 | - | 0 | Rosslyn | |
| 20 October 1877 | Clydesdale | 0 | - | 2 | Queen's Park | |
| 20 October 1877 | Dumbarton | 1 | - | 1 | Vale of Leven | |
| 20 October 1877 | Glengowan | 3 | - | 1 | Stonelaw | |
| 20 October 1877 | Govan | 1 | - | 0 | John Elder | |
| unknown | Grasshoppers | 3 | - | 0 | Clifton & Strathfillan | |
| 20 October 1877 | Hanover | 1 | - | 1 | Hibernian | |
| 20 October 1877 | Jordanhill | 2 | - | 1 | Lenzie | |
| 20 October 1877 | Lennox | 9 | - | 0 | Milngavie | |
| 27 October 1877 | Mauchline | 1 | - | 0 | Kilmarnock Cricket & Football Club | |
| 27 October 1877 | Maybole Carrick | 2 | - | 0 | Queen of the South Wanderers | |
| 20 October 1877 | Parkgrove | 2 | - | 1 | Kelvinbank | |
| 20 October 1877 | Partick | 8 | - | 1 | Strathclyde | |
| 27 October 1877 | Rangers | 8 | - | 0 | Alexandra Athletic | |
| 27 October 1877 | Renfrew | 2 | - | 1 | Glenkilloch | |
| 20 October 1877 | Renton | 3 | - | 0 | 10th Dumbarton Rifle Volunteers | |
| 20 October 1877 | Sandyford | 2 | - | 1 | Northern | |
| 20 October 1877 | South Western | 2 | - | 2 | Havelock | |
| 27 October 1877 | St Clement's | 3 | - | 0 | Dunmore | |
| unknown | Thornliebank | 1 | - | 0 | 23rd Renfrew Rifle Volunteers | |
| 20 October 1877 | Uddingston | 3 | - | 0 | Hamilton | |
| Bye | Barrhead | | | | | |
| Bye | Drumpelier | | | | | |
| Bye | Renton Thistle | | | | | |
| Bye | Stonefield | | | | | |
| Bye | Swifts | | | | | |
| Replay |
| 27 October 1877 | Havelock | 0 | - | 2 | South Western | |
| 27 October 1877 | Hibernian | 3 | - | 0 | Hanover | |
| 27 October 1877 | Kilbirnie | 3 | - | 1 | Ayr Thistle | |
| 27 October 1877 | Rovers | 0 | - | 0 | Blackfriars | Both teams advanced to next round |
| 27 October 1877 | Vale of Leven | 4 | - | 1 | Dumbarton | |
| Third round |
| 10 November 1877 | 3rd Lanark Rifle Volunteers | 1 | - | 0 | Queen's Park | |
| 10 November 1877 | Arthurlie | 0 | - | 0 | Thornliebank | |
| 10 November 1877 | Barrhead | 2 | - | 1 | Renfrew | |
| 10 November 1877 | Beith | 3 | - | 0 | Maybole Carrick | |
| 3 November 1877 | Blackfriars | 1 | - | 1 | Rovers | |
| 10 November 1877 | Drumpelier | 2 | - | 2 | Glengowan | |
| 10 November 1877 | Govan | 5 | - | 2 | Stonefield | |
| 10 November 1877 | Hibernian | 2 | - | 0 | Swifts | |
| 10 November 1877 | Jordanhill | 4 | - | 0 | Grasshoppers | |
| 10 November 1877 | Mauchline | 3 | - | 1 | Ayr Academicals | |
| 10 November 1877 | Parkgrove | 3 | - | 2 | Sandyford | |
| 17 November 1877 | Partick | 3 | - | 0 | Caledonian | |
| 10 November 1877 | Rangers | 13 | - | 0 | Uddingston | |
| 17 November 1877 | Renton | 2 | - | 0 | Renton Thistle | |
| 10 November 1877 | South Western | 4 | - | 0 | 1st Lanark Rifle Volunteers | |
| 10 November 1877 | Vale of Leven | 3 | - | 0 | Lennox | |
| Bye | Kilbirnie | | | | | |
| Bye | St Clement's | | | | | |
| Replay |
| 17 November 1877 | Glengowan | 0 | - | 0 | Drumpelier | Both teams advanced to next round |
| 10 November 1877 | Rovers | 1 | - | 0 | Blackfriars | |
| 17 November 1877 | Thornliebank | 2 | - | 0 | Arthurlie | |
| Fourth round |
| 1 December 1877 | 3rd Lanark Rifle Volunteers | 7 | - | 0 | Govan | |
| unknown | Barrhead | 0 | - | 0 | Partick | Match abandoned |
| Walkover | Beith | | | | St Clement's | Scratched |
| 1 December 1877 | Kilbirnie | 1 | - | 2 | Mauchline | |
| 1 December 1877 | Parkgrove | 3 | - | 1 | Drumpelier | |
| 1 December 1877 | Rangers | 0 | - | 0 | Vale of Leven | |
| 8 December 1877 | Renton | 4 | - | 0 | Rovers | |
| 1 December 1877 | South Western | 5 | - | 0 | Glengowan | |
| 1 December 1877 | Thornliebank | 1 | - | 2 | Hibernian | Match considered a draw after Thornliebank protest over one of Hibernian's goals |
| Bye | Jordanhill | | | | | |
| Replay |
| 8 December 1877 | Barrhead | 1 | - | 0 | Partick | Match declared void. Barrhead disqualified for discrepancies in their previous match against Renton. Both Partick and Renton reinstated |
| 8 December 1877 | Hibernian | 2 | - | 2 | Thornliebank | Both teams advanced to next round |
| 15 December 1877 | Vale of Leven | 5 | - | 0 | Rangers | |
| Fifth round |
| 5 January 1878 | 3rd Lanark Rifle Volunteers | 4 | - | 0 | Beith | |
| 29 December 1877 | Parkgrove | 1 | - | 1 | Partick | |
| 5 January 1878 | Renfrew | 0 | - | 2 | Mauchline | |
| 29 December 1877 | Renton | 2 | - | 1 | Thornliebank | |
| 29 December 1877 | South Western | 3 | - | 1 | Hibernian | |
| 22 December 1877 | Vale of Leven | 10 | - | 0 | Jordanhill | |
| Replay |
| 5 January 1878 | Partick | 1 | - | 2 | Parkgrove | |
| Quarter-final |
| 12 January 1878 | 3rd Lanark Rifle Volunteers | 0 | - | 1 | South Western | Match declared void |
| 12 January 1878 | Mauchline | 7 | - | 0 | Renton | Match declared void |
| 19 January 1878 | Vale of Leven | 5 | - | 0 | Parkgrove | |
| Replays |
| 19 January 1878 | Renton | 3 | - | 1 | Mauchline | |
| 19 January 1878 | South Western | 1 | - | 2 | 3rd Lanark Rifle Volunteers | |
| Semi-final |
| 16 February 1878 | Renton | 1 | - | 3 | 3rd Lanark Rifle Volunteers | Match declared void |
| Bye | Vale of Leven | | | | | |
| Replay |
| 9 March 1878 | Renton | 1 | - | 1 | 3rd Lanark Rifle Volunteers | aet |
| 2nd Replay |
| 16 March 1878 | 3rd Lanark Rifle Volunteers | 1 | - | 0 | Renton | |
| Final |
| 30 March 1878 | Vale of Leven | 1 | - | 0 | 3rd Lanark Rifle Volunteers | Played at 1st Hampden Park, Glasgow |
| 5,000 | McDougall (65) | | | | | Referee: Robert W Gardner (Glasgow) |
